Services

Notch Pathway

Notch Pathway Genes

Notch Signalling Genes involved in Apoptosis:

ASCL1, FOXC1, FOXC2, IL6ST, JAG2, ADAM17, APH1A, APH1B, KIT, NCSTN, NFKBIA, NOTCH1, NOTCH2, PSENEN, APP, PSEN2, TP63, PSEN1

Notch Signalling Genes involved in Cell Differentiation:

BMP10, DLL3, DLL4, DNER, DTX1, NLE1, NOTCH2NL, RBM15, NEUROD4, SOX2, FOXC1, ADAM17, KIT, NFKBIA, NOTCH2, PSEN2, TP63, DLL1, HES1, NOTCH4, NRG1, ASCL1, FOXC2, NOTCH1, PSEN1, MESP1, JAG2, JAG1

Notch Signalling Genes involved in Cell Proliferation:

HEY2, WDR12, NFKBIA, HES1, PSEN1, JAG1, ADAM10, IL6ST, APP, BMP10, SOX2, FOXC1, ADAM17, TP63, FOXC2, JAG2, KIT, NOTCH1, NOTCH2

Notch Signalling Genes involved in other roles:

CFD, CNTN1, CNTN6, DTX2, DTX3, DTX4, HES7, HEY1, HEYL, HOXD3, INTS6, MAML1, MAML2,, MAML3, MESP2, MIB1, MIB2, NCOR2, NOTCH3, POFUT1, RBPJ, SEL1L, SNW1, SPEN

Assessments we can conduct

1. Microarray Assessments:

• Custom Arrays containing multiple probe sets for all specified genes or pathways of interest
• Optional inclusion of the entire human, mouse or rat genome

2. qPCR analysis:

• Any specified genes or pathways of interest
• Each primer set designed and QC'ed by Epistem

3. Information from our proprietary PathwayDirect™ database containing extensive information on samples analysed by Epistem.

To obtain more information on monitoring the Notch pathway, please click here.

Microarray Analysis

Custom Array Analysis on any specified genes or pathways of interest. Optional inclusion of the entire genome.

qPCR Analysis

Any specified genes or pathways of interest.