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  • Epistem Biomarker Division
  • Epistem Plc
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  • Biomarker Discovery and Assay Development
  • Preclinical Applications
  • Clinical Applications
  • Drug Response and Predictive Drug Response
  • Patient Stratification
  • Companion Biomarkers for Drug Development Programs
  • Efficacy and Treatment Monitoring
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Applications

Biomarker Discovery and Assay Development

Our proprietary gene expression platform (GenetRx™) measures drug-induced gene expression changes in small amounts of tissue, for example a single human hair or other samples such as whole blood, fractionated PBMCs, tumour and tissue biopsies, FFPE and LCM samples, sputum, lavage and CSF. We are able to provide gene expression information from very small starting materials (as small as a single cell (10pg RNA input)), using our proprietary amplification technique.

Epistem use the GenetRx™ technology as a means of discovering:

• Novel drug-induced biomarkers
• Preclinical and clinical gene biomarkers of efficacy (PD)
• Drug mechanisms of action at a molecular pathway level

We provide biomarker discovery services as well as qPCR assay development services. For more information, please click here.